Titlebook: Starling’s Law of The Heart Revisited; H. E. D. J. Keurs,M. I. M. Noble Book 1988 Kluwer Academic Publishers 1988 heart

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Book 1988mechanical physiology. It is often forgotten that Frank and Starling carried out fundamentally different exper- iments. Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume-volume rela- tionship which depends directly on th

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The Mechanism of the Length-Tension Relation in Cardiac Muscle of Rana Catesbeiana, to obtain static and dynamic mechanical properties of single myofibrils consisting of only 20 to 30 sarcomeres. Isometric tension vs. sarcomere length curves of bull-frog single or double myofibrils were constructed with intracellular solutions having pCa values of 9.0, 6.0, 5.5 and 5.0 at several

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Intracellular Calcium Concentration Following Length Changes in Mammalian Cardiac Muscle,s to the shape of the length- tension relationship. Two mechanisms which could lead to such length-dependent activation are (i) changes in the amount of calcium supplied to the myofibrils and (ii) changes in the amount of calcium bound to the myofibrils for a given supply of calcium, e.g. by changes

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The Relation Between Contraction Dynamics and the Intracellular Calcium Transient in Mammalian Cardons through the surface membrane, release of Ca. ions from intracellular stores (sarcoplasmic reticulum), binding of Ca. to the C subunit of the regulatory protein troponin on the thin filament, conformational changes in the thin filament to uncover the myosin binding sites on actin molecules, the b

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Similarity and Dissimilarity Between Muscle Force-Length Relationship and Ventricular Pressure-Volutrasted with the isolated muscle end-systolic force-length relation which fell to the right of the isometric relationship. A discrepancy similar to that of isolated muscle appeared in later studies of the intact heart in which ejection fraction was greater. Further investigation showed that the disc

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The Importance of the Geometry of the Heart to the Pump, to be true, a model of the left ventricle can be constructed where these properties are achieved by appropriate orientation of fibres and torsional movement of the ventricle as a whole. The original cylindrical model was developed into one which was independent of ventricular shape. The equation:.P

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