Titlebook: Somatic Diversification of Immune Responses; Garnett Kelsoe,Martin F. Flajnik Book 1998 The Editor(s) (if applicable) and The Author(s), u

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Somatic Hypermutation of Immunoglobulin Genes is Linked to Transcription,e selected and develop into plasma cells or memory cells. B cells with mutations that decrease the affinity of the expressed Igs or that prevent Ig expression die by apoptosis. The somatic point mutations are located within the variable region and their proximate upstream and downstream flanks, but not generally within the constant region.

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The Role of Promoter-Intron Interactions in Directing Hypermutation,res in their environment. In a molecular recapitulation of this process, antibodies undergo a somatic evolution after antigen stimulation, resulting in a more protective defense of the host against the environment. Immunoglobulin genes undergo apparently random hypermutation of their rearranged vari

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Characteristics of Somatic Hypermutation of Human Immunoglobulin Genes,ion process that preserves those B lymphocytes with mutated surface immunoglobulin (Ig) expressing an increased affinity for the immunogen (. et al. 1989; . and . 1989; . and . 1996). The surviving B cells then give rise to memory B cells and antibody secreting cells. Hypermutation is the predominan

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