Titlebook: Skin Pharmacology and Toxicology; Recent Advances Corrado L. Galli,Christopher N. Hensby,Marina Mari Conference proceedings 1990 Springer S

START

The Evaluation of Cutaneous Toxicity: Past and Future,elates to occupational incidence but it is reasonable to suppose that misuse of household products in the home produces similar problems. Against this background, public concern and more encompassing legislation (3) has reinforced the need to evaluate chemicals and formulations for their potential t

glacial

nurture

Pro-Inflammatory Mediators and Human Skin Disease,one example being urticaria, to conditions such as psoriasis, which are characterised by a chronic cellular infiltrate. It has been suggested that the pathological changes associated with these skin diseases may be brought about by chemical mediators present in the involved tissue. Before any aspect

GEON

Chandelier

Molecular and Cellular Mechanisms of Multistage Carcinogenesis; Role of Oncogenes and Intercellular, including molecular biology studies and epidemiological analysis of human cancer (1–5). The latest evidence for the multistage nature of the carcinogenesis process has come from the use of transgenic mice which contain various introduced oncogenes (6,7). For example, in transgenic mice which harbo

frozen-shoulder

irreparable

A Comparative Evaluation of Sun Protective Properties of a Shea Butter by Reflectance Spectroscopy,ulation to have a soothing and calming effect on dry and sensitive skin (1). Due to the increasing number of reports of intolerance to synthetic sun protecting agents it is of interest to find and identify new “natural” sunscreens (2,3,4,5). It was the aim of the present study to compare two objecti

BILL

Nuclear Aberrations in Anagen Hair Follicle Cells; A Novel , Assay for the Detection of Genotoxic Aoints include micronuclei (Heddle, 1973; Schmid, 1973) as well as indicators of apoptosis (Kerr et al., 1972) such as pyknotic or karyorrhectic nuclei and vacuolated nuclear fragments appearing in cells after carcinogenic exposure (see Goldberg et al., 1983).

1FAWN

,Dermatological Drug Development — A Review of Some Important Issues,utics will be discussed. The author is an experienced pharmaceutical physician who practises as a clinical dermatologist and is therefore well placed to provide a commentary on these subjects but will, naturally, be strongly influenced by his background.

RACE

In Vitro Biochemical Markers of Skin Toxicity,he epidermis (differentiating cell layers) giving rise to the stratum corneum (permeability barrier). In developing in vitro models for the different expression of cutaneous toxicity (tab. 1), it is important to emulate this complexity as far it is feasible.