Titlebook: Severe Asthma in Children and Adolescents; Mechanisms and Manag Erick Forno,Sejal Saglani Book 2020 Springer Nature Switzerland AG 2020 sev

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Severe Asthma During Adolescence and the Transition to Adulthoodors for poor outcomes, and important issues to consider when we manage patients in this age group and help them prepare for the transition to young adulthood?– when patients are expected to become responsible for managing their disease.

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formal approach in the transition to adult care for adolesce.This book provides readers with a comprehensive review of severe asthma in children and adolescents, covering epidemiology, genetics, risk factors, co-morbidities, clinical presentation, diagnosis and treatment. Written by leaders in the f

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e current state and future avenues for severe asthma research.?.Severe Asthma in Children and Adolescents. is an indispensable reference for the healthcare professional, for basic and translational researchers,978-3-030-27433-7978-3-030-27431-3

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The Epidemiology of Severe Childhood Asthmarlier than those with mild/moderate disease and have early development of atopy and a T2-like diathesis. Severe asthma is often associated with comorbid condition, including obesity, rhinitis, nasal polyps, food allergy, and vocal cord dysfunction. An important determinant of severe asthma is a pred

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Asthma Plus: Comorbidities in Severe Childhood Asthmacient. This chapter discusses the known associations between comorbidities and asthma, highlighting data in pediatric severe asthma and effectiveness of interventions on improvement of asthma, where available.

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Immunotherapy and Immunomodulatorslled despite the use of inhaled corticosteroids. There are five FDA-approved biologics for the treatment of asthma in children and adolescents (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab). Multiple other potential targets are currently being investigated.

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Basic Mechanisms Underpinning Severe Childhood Asthmancluding increased thickness of the sub-epithelial reticular basement membrane and increased airway smooth muscle mass. However, the inflammatory and remodelling phenotype can also be very variable between patients. All studies demonstrate a large degree of variability within groups of patients with