Titlebook: Sequence — Evolution — Function; Computational Approa Eugene V. Koonin,Michael Y. Galperin Textbook 2003 Springer Science+Business Media Do

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Information Sources for Genomics,rom this information are not comfortable navigating these databases, let alone assessing the reliability of the data. This chapter is an attempt to bring the genomic databases closer to their principal users, molecular biologists and biochemists.

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Epilogue: Peering through the crystal ball,it is attractive to think of some real new avenues of research, those that are in their infancy now, but may be expected to flourish, say, in the year 2012. The images in the crystal ball are vague and we may easily take them for something that they are not, but since we are trying to think big, it will not be too embarrassing to miss the target.

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Comparative Genomics and New Evolutionary Biology,rtical inheritance, we now have the new notion of “genomes in flux” [787] . According to this concept, evolution involves gene loss and horizontal gene transfer as major forces shaping the genome, rather than isolated incidents of little consequence.

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Introduction: Personal Interludes,ors’ alma mater, by a well-known virologist, a scientist of rare creativity, and later a good friend, Anatoly Altstein. The subject of the seminar was a model of the origin of the genetic coding and translation he had developed [23]. The model was a beauty, but it was hard to imagine how one would g

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Evolutionary Concept in Genetics and Genomics,or she come from?” Affiliation with a certain family immediately provided a starting point for further inquiries, a general idea of what might be expected from a certain individual. Of course, families are never uniform, and classic literature from Homer to Shakespeare to Tolstoy provides ample illu

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Information Sources for Genomics,s combining disparate data from a variety of sources. Reliable information resources, compiling data on sequenced genomes and linking it to the wealth of associated functional data, are indispensable for comparative genomics. The amount of genome-related information stored in public databases and fr

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Principles and Methods of Sequence Analysis,analysis. Although these methods are not, in themselves, part of genomics, no reasonable genome analysis and annotation would be possible without understanding how these methods work and some practical experience with their use. Inappropriate use of sequence analysis procedures may result in numerou