Titlebook: Separation Techniques Applied to Omics Sciences; From Principles to R Ana Valéria Colnaghi Simionato Book 2021 The Editor(s) (if applicable

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Practical Considerations in Method Development for Gas Chromatography-Based Metabolomic Profiling,. The selection of column geometry and phase ratio impacts analyte mass transfer, which must be carefully optimized for fast analysis. Stationary phase selection is critical to obtain baseline resolution of critical pairs, but such selection must consider important aspects of metabolomic protocols,

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Capillary Electrophoresis-Mass Spectrometry for Metabolomics: Possibilities and Perspectives,d charged metabolites in a wide range of biological samples. Compared to other analytical techniques, the use of CE-MS in metabolomics is relatively low as the approach is still regarded as technically challenging and not reproducible. In this chapter, the possibilities of CE-MS for metabolomics are

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Liquid Chromatography-Mass Spectrometry for Clinical Metabolomics: An Overview,liquid chromatography and mass spectrometry technologies has driven an exponential progress in LC-MS-based metabolomics. Targeted and untargeted metabolomics strategies are important tools in health and medical science, especially in the study of disease-related biomarkers, drug discovery and develo

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Analytical Platforms for Mass Spectrometry-Based Metabolomics of Polar and Ionizable Metabolites,plex biospecimens. Liquid chromatography-mass spectrometry operated under reversed-phase conditions is the most commonly used platform in metabolomics, which offers extensive coverage for nonpolar and moderately polar compounds. However, complementary techniques are required to obtain adequate separ

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Metabolomics Data Treatment: Basic Directions of the Full Process,ain objectives and important considerations of each step. Initially, an overview of metabolomics and the pivotal techniques applied in the field are presented. Important features of data acquisition and preprocessing such as data compression, noise filtering, and baseline correction are revised focu

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The New Omics Era into Systems Approaches: What Is the Importance of Separation Techniques?,aningful progress in the omics era, conducting the classical molecular biology to contemporary systems biology. In this introductory chapter, the relevance of these techniques to the development of different omics sciences, within the systems biology context, will be discussed.

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Practical Considerations in Method Development for Gas Chromatography-Based Metabolomic Profiling,such as derivatization and dependence of analyte identification on existing databases. Sample preparation methods are also addressed depending on the sample matrix, including liquid-liquid extraction and solid-phase microextraction.

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Liquid Chromatography-Mass Spectrometry for Clinical Metabolomics: An Overview,pment, toxicology, diet, physical exercise, and precision medicine. Clinical and biological problems can now be understood in terms of metabolic phenotyping. This overview highlights the current approaches to LC-MS-based metabolomics analysis and its applications in the clinical research.

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