Titlebook: Semaphorins: Receptor and Intracellular Signaling Mechanisms; R. J. Pasterkamp Book 2007 The Editor(s) (if applicable) and The Author(s),

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The CRMP Family of Proteins and Their Role in Sema3A Signaling,by which CRMPs regulate cellular responses to Sema3A. In this review, the evidence for CRMP as a component of the Sema3A signaling cascade and the modulation of CRMP by plexin and phosphorylation are considered. In addition, current knowledge of the function of CRMP in a variety of cellular processe

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MICAL Flavoprotein Monooxygenases: Structure, Function and Role in Semaphorin Signaling,le well-conserved domains known for interactions with the cytoskeleton, cytoskeletal adaptor proteins, and other signaling proteins. In addition to their ability to bind other proteins, MICALs contain a large NADPH-dependent flavoprotein monooxygenase enzymatic domain. Although MICALs have already b

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Signaling of Secreted Semaphorins in Growth Cone Steering,ircuitry by mediating axon steering and fasciculation during development of the nervous system.–. Semaphorin 3A (Sema3A) was the first secreted form of semaphorins purified from adult chick brains and characterized as a chemorepellant with the ability to induce rapid collapse or repulsion of dorsal

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