Titlebook: Role of Transcription Factors in Gastrointestinal Malignancies; Ganji Purnachandra Nagaraju,Pallaval Veera‘Bramhac Book 2017 Springer Natu

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,HIF-1α: Its Role in Metastasis of Oesophageal Malignancy,tumors to hypoxia. Therefore, HIF-1α acts as a promising target in advancement of new therapeutics for oesophagus cancer therapy. Recent developments in regulation of HIF-1α and functional involvement in tumor growth, migration, stemness and drugs affecting HIF-1α expression will be discussed in this review.

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EXALT

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Transcription Factors and Colorectal Cancer: An Overview,involved in various CRC pathogenesis will be useful in designing novel therapeutic strategies specifically targeting the dysregulated transcription factors. This chapter emphasizes the role of major transcription factors and their dysregulation in CRC.

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Genistein and Its Role in Regulation of AP-1 in Colorectal Cancer,scription factor that regulates many oncogenic transduction pathways. In the current chapter, we discuss the importance of AP-1 on CRC growth and metastasis. Additionally, we discuss the mechanism of genistein, a tyrosine kinase inhibitor, and its effect on CRC treatment.

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,Curcumin Suppresses Colorectal Cancer Growth and Metastasis by Inhibiting NF-κB Activity,ncer’s ability to activate major transcription factors such as NF-κB. Curcumin, a phytochemical, is known to downregulate NF-κB signaling in CRC cell lines and to exhibit anticarcinogenic properties. Therefore, curcumin and its analogues are novel therapeutic agents that could be used in the treatment of CRC growth and metastasis.

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978-981-13-3893-9Springer Nature Singapore Pte Ltd 2017

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