Titlebook: Role of Melatonin and Pineal Peptides in Neuroimmunomodulation; Franco Fraschini,Russel J. Reiter Book 1991 Springer Science+Business Medi

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Demonstration of Nerve Fibers Immunoreactive to Met-Enkephalin, Leu-Enkephalin, and ?-Endorphin in ttion is transmitted to other areas in the central nervous system, particular areas involved in neuroendocrine regulation (Reiter, 1989). The neuronal pathway transmitting the information from the retina to the pineal gland involves the optic nerve, the suprachiasmatic nucleus and the superior cervic

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Pharmacological Regulation of Receptor-Mediated Indoleamine Metabolism in the Mammalian Pineal Glande pineal gland possesses unique features, such as receiving both peripheral and central innervations, being part of the central nervous system, yet existing outside of the blood-brain barrier, and exhibiting astonishing and often bewildering species-directed variations in synthesizing pineal indoles

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Regulation of Melatonin Synthesis and Release:Paracrine Relationships in Mammalian Pineal Glandympathetic innervation to the pineal gland plays a major role in controlling phasic melatonin and serotonin (5HT) release. Additionally central pinealopetal fibers participate in pineal control; these fibers contain several neuropeptides and possibly amino acids and biogenic amines. Norepinephrine (

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New Aspects Concerning the Regulation of Pineal Indoleamine Metabolism: Implications for Neuroimmunoumber of levels. Whereas the stability of the circadian production of melatonin is generally well documented, there are factors which clearly modify the 24 hour synthesis of this important hormone. Changes in either the duration of elevated melatonin, the amplitude of the nocturnal increase, or the

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High-Affinity Melatonin Receptors in Mammals: Localization, G-Protein Coupling and Signal Transductinity melatonin binding sites have recently been characterized in a number of tissues by several different laboratories. High-affinity sites have equilibrium dissociation constants (K. values) ≤ 200 pM at room temperature; K. values in most reports are ca 40 pM. High-affinity melatonin binding sites

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Melatonin Receptors in Discrete Areas of Rat and Hamster Brain: Modulation by Melatonin, Testosteronso a pronounced diurnal rhythm in biological response to melatonin (Reiter et al., 1976): Chronic administration of melatonin by multiple late afternoon injections elicits gonadal regression in hamsters (Tamarkin et al., 1976), white-footed mice (Glass and Lynch, 1982) and rats (Reiter et al., 1980)