Titlebook: Risk and Progression Factors in Carcinogenesis; H. K. Müller-Hermelink,H.-G. Neumann,W. Dekant Conference proceedings 1997 Springer-Verlag

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Glutathione-Dependent Bioactivation and Renal Toxicity of Xenobioticsns (Meister 1988, 1992). Due to the nucleophilicity of the sulfur atom and the antioxidant properties of glutathione, this tripeptide is an important factor in the detoxication of xenobiotics and oxidants (Boyland and Chasseaud 1969). The formation of glutathione .-conjugates from xenobiotics and th

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Cellular Stress Response: Stress Proteins — Physiology and Implications for Cancerat shock proteins (HSPs) by electrophoretically analyzing newly synthesized proteins in heat-shocked . larvae. Heat shock treatment usually results in a strong induction of a set of proteins which have been synthesized before at a low level. Concomitantly, the synthesis of most other proteins is red

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Two-Dimensional Polyacrylamide Gel Electrophoresis of Cancer-Associated Proteins years considerable effort has been made to define the genetic events involved in the etiology of cancer development. Indeed, molecular genetics has been highly successful in the demonstration that development of certain forms of human cancers, in particular, colorectal, lung, and breast, may arise

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Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells witic processes, including genomic imprinting and gene expression (Tilghman 1993). DNA hypomethylation is one of the possible causes and one of the consequences of mammalian neoplasia and also occurs in cultured cells after treatment with certain carcinogenic drugs (Spruck et al. 1993). Changes in DNA

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Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesises in cellular components other than the genome may influence — promote or inhibit — the process of malignant transformation. Among these extragenomic cellular components, the histories and the proteins of the nuclear matrix, consisting mainly of the nuclear pore complex and the nuclear lamins, are