Titlebook: Ricin and Shiga Toxins; Pathogenesis, Immuni Nicholas Mantis Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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Interaction of Ricin and Shiga Toxins with Ribosomes,eraction with ribosomal proteins plays an important role in the catalytic activity and ribosome specificity of RIPs. This review summarizes the recent developments in identification of the ribosomal proteins that interact with ricin and Shiga toxins and the principles governing these interactions.

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Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure,n the blood circulation. This chapter describes in detail the current knowledge of how these bacterial toxins may lead to kidney disease and renal failure. The toxin receptors expressed by specific blood and resident renal cell types are also discussed as are the actions of the toxins on these cells.

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Animal Models of Ricin Toxicosis,in non-human primates are most relevant for testing and developing agents having clinical utility. But these animals are expensive and limited in quantity, and so rodents are used for most mechanistic studies.

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Book 2012 and 39 deaths.? While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS).? At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC

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Obloquy

How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmi are liberated from the holotoxin. The free A chains are then dislocated, or retrotranslocated, across the ER membrane into the cytosol. Here, in contrast to ER substrates destined for proteasomal destruction, they undergo folding to a catalytic conformation and subsequently inactivate their cytosol

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Aqueous-Humor

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