Titlebook: Rheumatoid Arthritis; Methods and Protocol Shuang Liu Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Autoimmu

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Human Xenograft Modellogical system in NOD/SCID mice, RA patient-derived pannus tissue from the synovial membrane, articular cartilage, and bone can be transplanted subcutaneously. The same patient-derived peripheral blood mononuclear cell chimerism can be successfully achieved by intraperitoneal engraftment. This xenog

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Clinical Scoring of Disease Activity in Animal Modelsstological examination of joints. Clinical scoring using a qualitative scoring system of paw inflammation (paw thickness, width, or volume) over time is the standard method used for subjective quantification of arthritis activity. To evaluate paw swelling status, a quantitative method using three-di

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Production of Neutralizing Antibodysearch has been established based on their characteristics, including specificity of binding, homogeneity, and ability to be produced on a large scale. MAb immunoglobulins are the starting material for the generation of smaller antibody fragments and other engineered immunomodulatory antibodies. In

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Autoantibody Profiling Using Human Autoantigen Protein Array and AlphaScreenes. Analysis of autoantibodies is essential for investigating pathology mechanisms, diagnosis, and therapeutics of these diseases. We developed autoantibody profiling assay using cell-free synthesized protein array and high-throughput screening technology. Our assay system can sensitively detect int