Titlebook: Reviews of Physiology, Biochemistry and Pharmacology 149; S. G. Amara,E. Bamberg,M. Schweiger Book 2004 The Editor(s) (if applicable) and

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Book 2004e Regulation of Cytokine Signaling by CES/SOCS Family Proteins and Their Roles in Inflammatory Diseases..J. Kalesnikoff, L.M. Sly, M.R. Hughes, T. Büchse, M.J. Rauh, L.-P. Cao, V. Lam, A. Mui, M. Huber, and G. Krystal: The Role of SHIP in Cytokine-Induced Signaling.

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0303-4240 es, T. Büchse, M.J. Rauh, L.-P. Cao, V. Lam, A. Mui, M. Huber, and G. Krystal: The Role of SHIP in Cytokine-Induced Signaling.978-3-642-05777-9978-3-540-45205-8Series ISSN 0303-4240 Series E-ISSN 1617-5786

Dorsal

The role of SHIP in cytokine-induced signaling,IP1), the 104-kDa .tem cell-restricted SHIP (sSHIP) and the more widely expressed 150-kDa SHIP2 hydrolyze PI-3,4,5-P. to PI-3,4-P.. In this review we will concentrate on the properties of the three SHIPs, with special emphasis being placed on the role that SHIP plays in cytokine-induced signaling.

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Reviews of Physiology, Biochemistry and Pharmacologyhttp://image.papertrans.cn/r/image/829668.jpg

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IL-6 signal transduction and its physiological roles: the signal orchestration model,cidation of the molecular mechanisms underlying this issue is a challenging subject for future research. Intriguingly, recent in vivo studies indicated that the SHP-2-binding site- and YXXQ-mediated pathways through gp130 are not mutually exclusive but affect each other: a mutation at the SHP-2-bind

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J. Kalesnikoff,L. M. Sly,M. R. Hughes,T. Büchse,M. J. Rauh,L.-P. Cao,V. Lam,A. Mui,M. Huber,G. Kryst