| 書目名稱 | Retinoids |
| 副標題 | Advances in Basic Re |
| 編輯 | C. E. Orfanos (Director),O. Braun-Falco (Chairman) |
| 視頻video | http://file.papertrans.cn/830/829248/829248.mp4 |
| 圖書封面 |  |
| 描述 | With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre- sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio- transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are exc |
| 出版日期 | Conference proceedings 1981 |
| 關鍵詞 | Hautkrankheit; Retins?ure; cancer; skin disease; therapy |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-68023-6 |
| isbn_softcover | 978-3-642-68025-0 |
| isbn_ebook | 978-3-642-68023-6 |
| copyright | Springer-Verlag, Berlin Heidelberg 1981 |
|Archiver|手機版|小黑屋|
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