Titlebook: Retinoid and Rexinoid Signaling; Methods and Protocol Swapan K. Ray Book 2019 Springer Science+Business Media, LLC, part of Springer Nature

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Book 2019nologies to demonstrate the therapeutic activities of molecules. The chapters in this book cover topics such as lentiviral delivery of shRNA constructs into acute promyelocytic leukemia cells for ATRA induced differentiation and autophagy; methods to analyze RAR signaling in colorectal cancer cells;

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Targeting Non-Genomic Activity of Retinoic Acid Receptor-Gamma by Acacetin,ical targets and current drug development paradigms are largely based on their nuclear transcription mechanism (genomic action). However, the side effects and limited therapeutic efficacy of retinoid-like drugs with such strategy remain a problem in clinical practice. Increasing evidences have demon

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evasive

Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer,tion of RAR signaling often induces cell cycle arrest, differentiation, and apoptosis in many types of cells. Consequently, loss of normal RAR function in the presence of physiological levels of retinoic acid (RA) is often observed in cancers, and pharmacological reactivation of RAR signaling has be

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Methods to Assess Activity and Potency of Rexinoids Using Rapid Luciferase-Based Assays: A Case Stu(ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)nicotinic acid (.), as well as several . analog compounds recently reported by our group. These methods have general applicability beyond this NEt-TMN case study, and can be employed to characterize and biologically evaluate other pu