Titlebook: Retinal Pigment Epithelium in Health and Disease; Alexa Karina Klettner,Stefan Dithmar Book 2020 Springer Nature Switzerland AG 2020 Retin

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RPE Polarity and Barrier Functione selectivity and help determine permeability. In RPE, claudin-19 functions in coordination with RPE-enriched membrane transporters. Further, claudin-19 is a signaling protein that helps determine the RPE phenotype. Experimental assessments of the function of tight junctions are often reduced to the

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Ion Channels of the Retinal Pigment Epitheliumels such as anoctamin-2, bestrophin-1, CCl-2 or CFTR, K. channels such as Kir7.1 or KCNQ4/5 and Ca. channels such as Ca.1.3, TRPC or TRPV2. In particular, the analysis of Cl channels provided basic information on mechanisms of transepithelial transport of Cl. and water across the RPE. Furthermore, t

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The RPE in Myopia Development ultimately determine vitreous chamber depth and thus overall eye length. This chapter summarizes results of recent RPE studies, including RPE-derived growth factors, neurotransmitters and their receptors, ion channels, and RPE morphological changes in the context of eye growth regulation and myopia

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RPE and Stem Cell Therapyl-based therapies. Since 2004, numerous research groups have reported successful differentiation of functional RPE cells from hPSCs (hPSC-RPE) using a wide variety of methods. Two RPE cell transplantation strategies—each with their own pros and cons—are currently under development: injection of a si

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ts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.?.978-3-030-28386-5978-3-030-28384-1

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