Titlebook: Retinal Degenerative Diseases; Mechanisms and Exper John D. Ash,Christian Grimm,Catherine Bowes Rickma Conference proceedings 2014 The Edit

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Lack of Effect of Microfilament or Microtubule Cytoskeleton-Disrupting Agents on Restriction of Extept phagocytosis by the adjacent retinal pigment epithelium (RPE) every morning after light onset. Failure of this process causes retinal dystrophy in animal models and its decline likely contributes to retinal aging and some forms of degeneration of the human retina. We previously found that surface

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Rescue of Compromised Lysosomes Enhances Degradation of Photoreceptor Outer Segments and Reduces Lipthe onerous task of degrading both internal cellular debris generated through autophagy as well as phagocytosed photoreceptor outer segments. We propose that the inadequate processing material with the resulting accumulation of cellular waste contributes to the downstream pathologies characterized a

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Vacuolar ATPases and Their Role in Visionelium (RPE) and photoreceptor outer segment (OS) phagocytosis, an event linked to retinal degeneration. As the RPE plays essential roles in eye development and vision, the study of v-ATPase-induced RPE dysfunction may improve our understanding of RPE diseases.