Titlebook: Retinal Degenerative Diseases; Mechanisms and Exper Catherine Bowes Rickman,Christian Grimm,Joe G. Hol Conference proceedings 2019 Springer

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AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microgliaotypes. Here, we show that an HtrA1 isoform carrying AMD-associated SNPs in exon 1 exhibits increased proteolytic activity. However, when incubating TGF-β-treated reactive microglia with HtrA1 protein variants, neither the wildtype nor the SNP-associated isoforms changed microglia activation in vitro.

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A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a?Focus ppreciate the different known morphological endpoints associated with the various pathogenic pathways, in order to derive further insights, for the ultimate purpose of disease modeling and development of effective therapeutic interventions.

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Melatonin as the Possible Link Between Age-Related Retinal Degeneration and the Disrupted Circadian e a major factor contributing to the impaired balance between phagocytosis and clearance and increased levels of reactive oxygen species resulting in degenerative changes in the retina. This minireview summarizes studies linking AMD with melatonin production and discusses challenges and perspectives of this area of research.

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