Titlebook: Respiratory Regulation - The Molecular Approach; Mieczyslaw Pokorski Conference proceedings 2013 The Editor(s) (if applicable) and The Aut

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Indacaterol Add-On Therapy Improves Lung Function, Exercise Capacity and Life Quality of COPD Patieflow limitation, and pulmonary hyperinflation, resulting in dyspnea, decreased exercise tolerance, and impaired quality of life. COPD pharmacotherapy guidelines are based on a combination of long-acting beta2-agonists (LABA), long-acting antimuscarinic agents (LAMA) and methyloxantins. Recently, ind

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Effects of Selective Inhibition of PDE4 and PDE7 on Airway Reactivity and Cough in Healthy and Ovalt in respiratory diseases associated with inflammation. The aim of the present study was to evaluate the effects of selective PDE4 (rolipram, ROL) and PDE7 inhibitors (BRL50481, BRL) on citric acid-induced cough, . and . airway smooth muscle reactivity in both healthy and ovalbumin sensitized guinea

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Naloxone Blocks Suppression of Cough by Codeine in Anesthetized Rabbits,he present study we examined the effects of naloxone, a μ-opioid receptor antagonist, on mechanically-induced tracheobronchial cough and on the cough suppressing effect of codeine in six pentobarbitone anesthetized spontaneously breathing rabbits. A single dose of naloxone (0.4 mg/kg) followed by a

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Influence of Sublingual Immunotherapy on the Expression of Mac-1 Integrin in Neutrophils from Asthmic patients is largely unknown. Mac-1 integrin is a transmembrane protein containing α (CD11b) and β (CD18) chains. High expression of the complex is found on the surface of neutrophils, NK cells, and macrophages. CD11b/CD18 may bind to CD23, ICAM-1, ICAM-2, and ICAM-4. It plays a crucial role in di

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