Titlebook: Resolving the Antibiotic Paradox; Progress in Understa Barry P. Rosen,Shahriar Mobashery Book 1998 The Editor(s) (if applicable) and The Au

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Metalloid Resistance Mechanisms,drug uptake systems. The most common mechanism of resistance to drugs and antibiotics is through the expression of genes for extrusion systems that reduce the intracellular concentration to subtoxic levels.. The treatment of clinical drug and antibiotic resistance requires knowledge of the routes of

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The Impact of Bacterial Genomics on Antibacterial Discovery,within the pharmaceutical industry resulted in the discovery of virtually all the current, structurally diverse, antibiotic classes with clinical utility. Indeed, based on the perceived potential for these drugs, by the end of the 1960’s it was widely believed that bacterial infection would soon be

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Design, Synthesis, and Evaluation of Novel Oxazolidinone Antibacterial Agents Active Against Multidximately one third of the world’s population is infected with . and tuberculosis remains the leading cause of death in the world from infectious disease (Bloom, 1994). The emergence of effective antibacterial agents, from penicillin to more contemporary drugs, was initially thought to mark an end to

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Concept, Design, and Preclinical Evaluation of Quinolonyl Lactam Antibacterials,unbeatable contagious infectious diseases have already generated significant medical crises in localized environments. Such crises may become more widespread, perhaps in the not too distant future. Laboratories worldwide have responded with highly creative research programs, many of which are review

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Bacterial Two-Component Signalling as a Therapeutic Target in Drug Design, and Sanchez, 1997). In the US, overall mortality from infectious diseases has increased 58% with deaths from respiratory infections and septicemia up 20 and 83% respectively (Pinner et al., 1996). Increased resistance has been documented for every major group of pathogens with methicillin resistant

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