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Titlebook: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways; Yosef Yarden,Moshe Elkabets Book 2018

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書(shū)目名稱Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
編輯Yosef Yarden,Moshe Elkabets
視頻videohttp://file.papertrans.cn/829/828448/828448.mp4
概述Comprehensively covers the multiplicity and diversity of mechanisms underlying resistance to the currently approved drugs, both tyrosine kinase inhibitors and monoclonal antibodies, that specifically
叢書(shū)名稱Resistance to Targeted Anti-Cancer Therapeutics
圖書(shū)封面Titlebook: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways;  Yosef Yarden,Moshe Elkabets Book 2018
描述.This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance..
出版日期Book 2018
關(guān)鍵詞Anti-cancer; Kinases; Resistance; Tyrosine; therapeutics
版次1
doihttps://doi.org/10.1007/978-3-319-67932-7
isbn_softcover978-3-030-09817-9
isbn_ebook978-3-319-67932-7Series ISSN 2196-5501 Series E-ISSN 2196-551X
issn_series 2196-5501
copyrightSpringer International Publishing AG, part of Springer Nature 2018
The information of publication is updating

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https://doi.org/10.1007/978-3-319-67932-7Anti-cancer; Kinases; Resistance; Tyrosine; therapeutics
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RAF, MEK and ERK Inhibitors as Anti-Cancer Drugs: Intrinsic and Acquired Resistance as a Major Therd cancers. Several resistance mechanisms have been proposed up to date, which result from either preexisting mechanisms in some or all cells within the tumors or due to drug-induced mechanisms. These include (a) expression of drug-resistant RAF isoforms (b) molecular or genetic alterations of downst
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