Titlebook: Research in Computational Molecular Biology; 22nd Annual Internat Benjamin J. Raphael Conference proceedings 2018 Springer International Pu

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0302-9743 is, France, in April 2018..The 16?extended and 22 short abstracts?presented were carefully reviewed?and selected from 193 submissions. The short abstracts are included in?the back matter of the volume. They report on original research in all?areas of computational molecular biology and bioinformatic

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Chromatyping: Reconstructing Nucleosome Profiles from NOMe Sequencing Data,ities of that graph can be efficiently computed using Hidden Markov Models. We demonstrate using simulated data that ChromaClique is more accurate than a related method and scales favorably, allowing genome-wide analyses of chromatypes in cell subpopulations. Software is available at . under MIT license.

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A Nested 2-Level Cross-Validation Ensemble Learning Pipeline Suggests a Negative Pressure Against C snoRNA-mRNA in Saccharomyces Cerevisae, our results suggest the existence of a repression of ncRNA affinities with mRNAs, and thus the existence of an evolutionary pressure inhibiting such interactions.

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Context-Specific Nested Effects Models,work. Biologically, the representation of regulators in multiple contexts may indicate that these regulators have distinct roles in different cellular compartments or cell cycle phases. We present an evaluation of the method on simulated data as well as on data from a study of the sodium chloride stress response in ..

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