Titlebook: Research in Computational Molecular Biology; 19th Annual Internat Teresa M. Przytycka Conference proceedings 2015 Springer International Pu

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Efficient Alignment Free Sequence Comparison with Bounded Mismatches,mance. In this paper, we close the gap by presenting the first provably efficient algorithm for the .. (.) problem that takes . space and . time in the worst case for any constant .. Our method extends the generalized suffix tree model to incorporate a carefully selected bounded set of perturbed suf

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Learning Microbial Interaction Networks from Metagenomic Count Data,el, but not SparCC or glasso, correctly resolves a direct interaction structure among three community members that associate with . roots. We conclude that our method provides a structured, accurate, and distributionally reasonable way of modeling correlated count based random variables and capturin

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KGSrna: Efficient 3D Kinematics-Based Sampling for Nucleic Acids, analysis-based exploration, our procedure diffuses faster through the experimental ensemble while also accessing conformational substates to greater precision. Our results suggest that conformational sampling with a highly reduced but fully atomistic representation of noncoding RNA expresses key fe

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Efficient and Accurate Multiple-Phenotypes Regression Method for High Dimensional Data Considering e positive identifications. We further apply our method to genetic studies of yeast and gut microbiome from mouse and show that GAMMA identifies several variants that are likely to have a true biological mechanism.

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