Titlebook: Research in Computational Molecular Biology; 16th Annual Internat Benny Chor Conference proceedings 2012 Springer-Verlag Berlin Heidelberg

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Structure-Guided Deimmunization of Therapeutic Proteins,gs requires solving a unique set of challenges. For instance, it is increasingly apparent that mitigating potential anti-therapeutic immune responses, driven by molecular recognition of a therapeutic protein’s peptide fragments, may be best accomplished early in the drug development process. One may

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Conference proceedings 2012, held in Barcelona, Spain, in April 2012. The 31 revised full papers presented together with 5 keynote lectures were carefully reviewed and selected from 200 submissions. The papers feature current research in all areas of computational molecular biology, including: molecular sequence analysis; rec

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,: A Ball-Based Algorithm for Structural Motifs,. . combines the best properties of previously developed methods, exploiting the composition and local geometry of a structural motif and its possible instances in order to effectively filter candidate matches. We show that on a wide range of motif matching problems, . efficiently and effectively fi

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Evolution of Genome Organization by Duplication and Loss: An Alignment Approach,angements, we show that a direct approach based on dynamic programming leads, at best, to an efficient heuristic. We present an exact pseudo-boolean linear programming algorithm to search for the optimal alignment along with an optimal scenario of duplications and losses. Although exponential in the

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Network-Based Prediction and Analysis of HIV Dependency Factors,r in AIDS progression. Our results suggest that many HDFs are yet to be discovered and that they have potential value as prognostic markers to determine pathological outcome and the likelihood of AIDS development. More generally, if multiple genome-wide gene-level studies have been performed at inde