Titlebook: Research Procedures and Data Analysis; James C. Wilson,F. Clarke Fraser Book 1978 Springer Science+Business Media New York 1978 animal stu

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The Design of Subprimate Animal Studies3; Wilson, 1973; Swiss Academy of Medical Sciences, 1974). It is, therefore, well nigh impossible to find a novel line of approach to the subject, and there must inevitably be a great deal of repetition.

TSH582

Congestion

OUTRE

Cell, Tissue, and Organ Culture as Teratologic Toolsf these scientific approaches. Although in the strict sense the study of teratology implies environmental agents, the effect of mutant genes in development is so obviously related that some consideration will be given to the latter area in this discussion. Technical advances in these areas now offer

defuse

Whole Embryo Explants and Transplantscribed the cleavage of the one-cell stage. Heape (1890) made the first classic experiment in egg transfer, injecting eggs from an Angora rabbit into a Belgian Hare rabbit and successfully obtaining the birth of Angora young. Following this pioneer work, the science (some would say art) of mammalian

易怒

Survey of , Systems: Their Potential Use in Teratogenicity Screening testing for teratogenicity in anything less than a pregnant mammal has generally been rejected by the scientists and regulatory officials who are responsible for safety evaluations. This aversion has been based on the sound premise that the maternal-placental-embryonic relationship could not be dup

novelty

The Structure and Uses of Genetically Homogeneous Lines of Animalsviously. To discuss this question fruitfully it is necessary to remember that, like the phenomena teratologists explore, the purposes of teratological studies are many and varied. The means of attaining these purposes must therefore also be diverse.

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Multigeneration Reproduction Studies human population at all stages of exposure, including pregnancy. Foi food additives, pesticides, and all types of environmental contaminants, exposure is usually chronic, but exposure to drugs may be acute or chronic. It is generally agreed that in testing procedures the exposure of laboratory anim

MINT

Psychogenic