Titlebook: Reproductive Immunology; Satish K. Gupta (Chief) Book 1999 Springer Science+Business Media Dordrecht 1999 Antigen.HIV.immunobiology.infect

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Regulation of Development of Peri-Attachment Embryos: Comparative studies in rodents-implantation development is complex and difficult to study in vivo. To understand these processes, in vitro culture systems are required to achieve normal and viable peri-attachment embryo development. Using rodents (hamsters, mice and rats), we show that in vitro development of peri-attachment emb

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The Potential Role of Endoglin During Pregnancy, throughout pregnancy. It is also transiently expressed on differentiating extravillous trophoblasts (EVT) in anchoring villi. Interference with endoglin expression using antibodies or antisense oligonucleotides in human villous expiants in culture, induces EVT differentiation along the invasive pa

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Control of Maternal Immunity to Trophoblasthoblast and syncytiotrophoblast from this damage. The control of NK attack has been studied using the antibodies normally made against the R80K antigen of trophoblast. These antibodies have been shown to block NK activity against target cells, and tropboblast. The monoclonal antibody, BAH, against R

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Immunomodulation in Normal Pregnancy and Pre-Eclampsiaes towards type-2 responses. The corollary of this hypothesis is that a bias towards type-1 responses will be detrimental to pregnancy. Many of the features of the maternal syndrome of pre-eclampsia could be caused by inappropriate activation of maternal inflammatory cell responses. To investigate t

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Localisation of the Th2 Cytokines IL-3, IL-4, IL-10 at the Murine Feto Maternal Interface During Prethese data are in agreement with the concept of a strong Th2 cytokine shield at placental level in early gestation, with a slight decrease at term, whose regulation is discussed. Finally, we also show using 1 pr congenics that a prominent role for the Fas/Fas ligand system is not mandatory for ensuring the success of allogeneic pregnancy.