Titlebook: Reproductive Endocrinology; A Molecular Approach Pedro J. Chedrese Book 2009 Springer-Verlag US 2009 endocrinology.genomics.intracellular s

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FSH: One Hormone with Multiple Forms, or a Family of Multiple Hormonesde variety of activities in both male and female reproductive tissues including growth, division, and differentiation of Sertoli and granulosa cells. As a result, FSH is directly involved in the production of both male and female gametes, as well as production of hormones (estradiol and inhibin) tha

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The FSH Receptor: One Receptor with Multiple Forms or a Family of Receptorsity in response to secretion of FSH from the pituitary gland. Specific reproductive tissues within both males and females express the FSHR, and thus FSH has important roles in the reproductive process in both genders. This chapter will describe the location and expression of the FSHR gene within the

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Regulation of the Early Steps in Gonadal Steroidogenesisal cells of the ovary. Other major sites of de novo steroid biosynthesis include the placenta, the adrenal cortex, and the brain. In steroidogenic cells, cholesterol is taken up in response to trophic stimuli and transported into the mitochondria through the action of the steroidogenic acute regulat

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DNA Microarray Analysiss types include those for DNA, tissue, protein, and bacteria. DNA microarrays include those covering the whole genome, intergenic regions, and the coding regions of genes. Within this chapter we will focus on DNA microarrays with emphasis on arrays for analyzing gene expression.

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The FSH Receptor: One Receptor with Multiple Forms or a Family of Receptors gonads, post-transcriptional and post-translational modifications of FSHR protein, mechanisms of FSH binding and activation of the FSHR, and signaling events that occur within cells following FSH binding.

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Extracellular Signaling Receptors intracellular signaling pathways, which amplify the signal and affect gene expression. Thus, receptors not only receive extracellular signals but also increase and transmit those signals to the genome and ultimately elicit a biological response.

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Molecular Basis of Abnormal Phenotyperucture, function, and behavior that result from gene expression. Identical alleles located at the same locus on each of the matching chromosomes are considered . for a trait, while two different alleles are .. The allele expressed by phenotype is said to be . while the other allele, which is masked by the dominant gene, is described as ..

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Book 2009ted. Beginning in the 1970s, with nucleic acid enzymology and the discovery of the restriction enzymes, the tools of molecular biology became widely available and applied in cell biology to study how genes are regulated. This new knowledge impacted endocrinology and reproductive biology since it was