Titlebook: Relaxin and Related Peptides; Alexander I. Agoulnik Book 2007 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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https://doi.org/10.1007/978-0-387-74672-2Insulin; Peptides; Receptor; Relaxin; biological functions; molecular mechanisms; signaling pathways

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,Diverse Signalling Mechanisms Used by Relaxin in Natural Cells and Tissues: The Evolution of a “Neoutely dependent on a tyrosine kinase activity linked closely to the relaxin receptor. Relaxin may also independendy activate glucocorticoid receptors. This diversity of signalling leads to a broad range of possible downstream transcriptional effects. Finally, in tissues where relaxin is known to be

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Relaxin and Related Peptides in Male Reproduction,xpressed in testicular fetal and adult Leydig cells and is directly responsible for the process of abdominal testicular descent (migration of the testes towards the scrotum during male development). Genetic targeting of the . gene or INSL3 GPCR receptor . causes high intra-abdominal cryptorchidism d

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The Effects of Relaxin on Extracellular Matrix Remodeling in Health and Fibrotic Disease,d in particular, collagen at multiple levels, relaxin has emerged as a potent anti-fibrotic therapy, with rapid-occurring efficacy. It not only prevents fibrogenesis, but also reduces established scarring (fibrosis), which is a leading cause of organ failure and affects several tissues regardless of

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