| 書目名稱 | Regulatory Nascent Polypeptides | | 編輯 | Koreaki Ito | | 視頻video | http://file.papertrans.cn/826/825746/825746.mp4 | | 概述 | Highlights an emerging paradigm: proteins can function during their biosynthesis.Is the first book to focus on hitherto unpredicted functions of nascent chains.Explains how dynamic translation process | | 圖書封面 |  | | 描述 | .This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a haltin the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outpu | | 出版日期 | Book 2014 | | 關(guān)鍵詞 | Elongation Arresting; Nascent Polypeptide; Ribosome Stalling; Translation; Translational Regulation; gene | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-55052-5 | | isbn_softcover | 978-4-431-56113-2 | | isbn_ebook | 978-4-431-55052-5 | | copyright | Springer Japan 2014 |
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