Titlebook: Regulation of microRNAs; Helge Gro?hans Book 2010 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Sci

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miRNAs Need a Trim,e ., mouse and human Trim-NHL proteins are potential and in several cases confirmed, E3 ubiquitin ligases. Current research is focused on identifying targets and pathways for Trim-NHL-mediated ubiquitination and in assessing the contribution of the NHL protein-protein interaction domain for function

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Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression,NA 3′ untranslated regions (3′utrs), which are recognized by RNA-binding proteins (RBPs) and microRNAs (miRNAs). These factors greatly influence translational efficiency and stability of target mRNAs and often also determine their cellular localization. HuR, a ubiquitously expressed member of the El

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Turnover of Mature miRNAs and siRNAs in Plants and Algae,n eukaryotes. These small RNAs generally trigger the silencing of cognate sequences through a variety of mechanisms, including RNA degradation, translational inhibition and transcriptional repression. In the past few years, the synthesis and the mode of action of miRNAs and siRNAs have attracted gre

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