Titlebook: Regulation of Smooth Muscle Contraction; Robert S. Moreland Book 1991 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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0065-2598 uestions. I believe that after reading the chapters included in this volume, you will agree that this goal was achieved. The importance of calcium and calmoduli978-1-4684-6005-6978-1-4684-6003-2Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Tribute to Professor Edith Bülbringareer, she received many honors for her work on the fundamental properties of smooth muscle including: Schmiedeberg-Plakette der Deutschen Pharmakologischen Gesellschaft; honorary memberships in the Italian Pharmaceutical Society, British Physiological Society, and German Physiological Society; hono

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Regulation of Smooth Muscle Myosin Light Chain Kinase by Calmoduline different. Striated muscles utilize troponin C as the Ca. receptor and contain an array of cell specific proteins involved in maintenance of Ca. homeostasis. Phosphorylation reactions are important in regulation of contraction but phosphorylation of myosin light chains does not play a major role i

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Regulation of Smooth Muscle Actomyosin Function0 kDa light chain of myosin (Hartshorne, 1987). The enzyme which is responsible for the phosphorylation is the Ca./calmodulin dependent myosin light chain kinase (MLCK) and this is the key enzyme to confer Ca. sensitivity to the smooth muscle contractile apparatus (Hartshorne, 1987). Another critica

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Biochemical and Functional Characterization of Smooth Muscle Calponincle taking advantage of its heat-stability. The isolated protein was shown to bind calmodulin (by affinity chromatography) in a Ca.-dependent manner, and F-actin or F-actin-tropomyosin (by analytical ultracentrifugation) in a Ca.-independent manner. Its tissue content was estimated to be equi-molar

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Evidence for Smooth Muscle Crossbridge Mechanical Interactionssbridge mechanism in smooth muscle is qualitatively similar to that in skeletal muscle, smooth muscle has the unique ability of sustaining prolonged contractions with very little energy expenditure (Butler and Siegman, 1983). This economy of energy consumption may reflect a modulation of crossbridge

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Regulation of a Smooth Muscle Contraction: A Hypothesis Based on Skinned Fiber Studiesill considerable controversy concerning the explicit mechanism(s) coupling calcium to contraction. Bremel (1974), using filament displacement studies, showed that the Ca. dependence of vertebrate smooth muscle contraction is associated primarily with the thick filament. A few years later, Aksoy et a

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Mechanics of the Crossbridge Interaction in Living and Chemically Skinned Smooth Musclents to binding sites on “thin” actin-containing filaments. According to the crossbridge model formulated by Huxley (1957) and extended by Huxley and Simmons (1971), the rate constants for attachment and detachment are functions of the position of the crossbridge relative to the binding site on the a