Titlebook: Regulation of Gene Expression; Gary H. Perdew,John P. Heuvel,Jeffrey M. Peters Book 2007 Humana Press 2007 Proteomics.RNA.Termination.Tran

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Messenger RNA Accumulation with its strengths and weaknesses. Surprisingly, few investigators give much thought as to whether their methodologies and approaches are appropriate. Yet, the quantification and interpretation of results depends on understanding some key points. Three key factors contribute to the complexity and d

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Transcriptional Regulation of Gene Expressionter, the exploration of the reason for this accumulation commences. The two major ways in which the steady-state levels of a transcript are altered are via transcriptional or posttranscription processes. For simplicity, effects at the chromatin level will be included in this chapter. A summary of th

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Protein Synthesis and Turnoverte of protein synthesis or mRNA translation. Protein synthesis can be divided into three discreet steps; initiation, elongation, and termination. An important aspect of overall regulatory control of protein synthesis is regulation of peptide chain elongation by a group of eukaryotic elongation facto

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Proteomicss. Especially considering that changes in protein levels can occur without any change in an individual protein’s mRNA levels. Changes in translational rates, protein stability, protein localization, or posttranslational modifications can all lead to altered protein levels or activity. Only through t

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Posttranslational Modificationsies, and other protein activities mediated through protein-protein interactions. Because of the large number of posttranslational modifications that occur, this chapter will focus on the modifications that are most frequently encountered when examining regulation of gene expression through transcrip