Titlebook: Regenerative Medicine: Laboratory to Clinic; Asok Mukhopadhyay Book 2017 Springer Nature Singapore Pte Ltd. 2017 Organ regeneration.stem c

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Physico-Chemical Properties of the Stem Cell Niche makeup. There have been quite extensive studies on soluble factors which are found essentially in the extracellular matrix, in the case of adult as well as embryonic stem cells. Recent work has begun to elucidate that in addition to these biochemical signals from coordinated interactions with solub

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Ideal Stem Cell Candidate for Regenerative Medicine: Pluripotent Stem Cells, Adult Stem Cells, or Plogists observed that hematopoietic stem cells (HSCs) in bone marrow possess considerable “plasticity” and could replace hESCs for regenerative medicine. As a result several trials using autologous bone marrow cells were undertaken; however, no significant success has been achieved. Human ESCs and in

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Pancreatic Progenitors as Target for Islet ,genesis to Manage Diabetes years ago; however, shortage of donor pancreas and autoimmune rejections has limited their clinical implications. Although attempts are being made to generate islets from pluripotent stem cells, their clinical applications are restricted due to ethical concerns and teratoma formation. To overcome t

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Cell Therapy in Liver Diseasesseased liver, this safeguard of native regenerative capacity of the liver is severely compromised due to cellular and functional loss of regenerating cells leading to liver failure and death of the patients. Even today, the available therapeutic options for most of the hepatic diseases have limited