Titlebook: Regenerative Medicine for the Inner Ear; Juichi Ito Book 2014 Springer Japan 2014 Cochlear Implant.Hair Cell.Inner Ear.Regenerative Medici

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Cochlear Implant: Past, Present, and Future hearing loss. During the early years of cochlear implantation, postlingually deaf adults with normal cochlear anatomy received a cochlear implant (CI); however, the frequency of cochlear implantation in congenitally deaf children, children with inner ear malformations, and children with multiple di

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Recent Progress in Cochlear Implantture of the cochlea. With these improvements, the electrode array causes less trauma, and preservation of residual inner ear function is possible. Newly developed speech coding strategies are based on the psychology of hearing. The fine structure of speech is reproduced by mimicking the temporal exc

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Regenerative Medicine in Cochlear Implantationited when there is a primary auditory neuron response deficiency. To overcome this limitation, several strategies have been developed for the preservation or regeneration of spiral ganglion cells, i.e., primary auditory neurons. Among those strategies, the administration of neurotrophic factors and

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Synaptic Contacts Between Hair Cells and Primary Neuronsthe presynaptic region. Synaptic ribbons play a crucial role in glutamate release to the afferent nerve endings. This chapter reviews basic anatomy of synaptic contacts between hair cells and primary neurons and discusses on the importance of ribbon synapses in inner hair cells of the cochlea as a therapeutic target.

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Book 2014enerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the

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Stereocilia bundles. In this chapter we describe the molecular mechanisms underlying development and function of hair bundles. By exploiting this developmental knowledge it may be possible to generate hair cell-like cells and thus provide an alternative approach to regeneration-based cell therapies.

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Tectorial Membrane of TM and hearing loss. Alpha-tectorin mutations are also known to cause hearing loss in humans, including stable moderate to severe hearing loss and progressive hearing loss. Abnormal TM morphology is also observed in patients with idiopathic sudden sensory hearing loss, suggesting the vulnerability of TM to inflammatory processes.