Titlebook: Red Cell Membrane Transport in Health and Disease; Ingolf Bernhardt,J. Clive Ellory Book 2003 Springer-Verlag Berlin Heidelberg 2003 Trans

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Human Red Cell Shape and the Mechanical Characteristics of the Membrane,orces exerted by the suspending fluid on the red cell membrane are large the red cell shows liquid behaviour; i.e. it behaves similarly to a liquid drop in that its interior participates in flow (Schmid-Sch?nbein and Wells 1969; Fischer et al. 1978; Fischer 1978). This behaviour rests on the fact th

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Passive Membrane Permeability for Ions and the Membrane Potential,a distribution, established during evolution, is of fundamental importance for the regulation of cellular metabolism as well as for processes of signal transduction and excitation. The maintenance of the intracellular cation concentration as well as the cell volume is based on the balance between ac

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Ion Channels,ehensive picture has been established for mammalian erythrocytes, especially human, which will be the focus of this chapter. Among the pathways for passive, conductive transport of inorganic ions, two different cation channels have been extensively characterized at present, an intermediate conductan

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The Swelling-Sensitive Osmolyte Channel,nerally freely permeable to water, any such gradient results in flow of water into or out of the cell inducing cell volume perturbation. Regulation of cellular volume, which is important for cells to function properly, is achieved by activation of membrane transport processes. In response to swellin

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Na+-K+-2Cl- Cotransport,tributed to an impressive understanding of this complex transport protein. In recent years, significant advances have been made in discerning the structure, regulation, and physiological functions of electroneutral salt transporters. Here we review salient features of NKCC and then consider its poss

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K+-Cl- Cotransport in Vertebrate Red Cells,d volume. It emphasised the importance of a specific, ouabain-sensitive, Na./K. pump, driven by ATP, as the primary active transport process for maintaining high intracellular K., balancing K. loss through passive processes. The passive pathways were not defined. For many years, they were thought of

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Band 3 Mediated Transport,l. 1989) version of human AE1 (hAE1) is found primarily, though not exclusively (Papageorgiou et al. 2001), in red blood cells, where it mediates the very tightly coupled exchange of Cl. for HCO.. This permits HCO. formed from CO. in the systemic capillaries by the intracellular enzyme carbonic anhy

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Amino Acid Transport,leotides or other metabolically important nutrients, the twenty-three or so amino acids are more diverse in size, charge and structure, making it necessary to have several transporters with different substrate specificities. The pioneering work of Christensen (e.g. Christensen 1985; Christensen and