Titlebook: Red Blood Cell Aging; Mauro Magnani,Antonio Flora Book 1991 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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Behaviour of Glucose-6-Phosphate Dehydrogenase during Erythroid MaturationGlucose-6-phosphate dehydrogenase (G6PD; D-glucose-6-phosphate: NADP. oxidoreductase, EC 1.1.1 49) is the first enzyme of the hexose monophosphate pathway and provides NADPH essential for a variety of biosynthetic and detoxifying reactions (1).

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Significance and Relevance of NAD Synthesis in Human Erythrocyte Life SpanNAD and NADP are known to play a key role in the general metabolism of human erythrocytes, owing to their involvement in all oxidative-reductive reactions occuring both in the energetic catabolism and in the processes preventing the cells from oxidative damage.

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Synthesis of the Transferrin Receptor in Peripheral Sheep Reticulocytes: Evidence for Incomplete Olirom stem cell to circulating erythrocyte. In fact, it may almost be true to say that the red cell continuously changes until its senescent properties are recognized and it is eliminated from the circulation.

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Synthesis of the Transferrin Receptor in Peripheral Sheep Reticulocytes: Evidence for Incomplete Olicularly true in the study of membrane proteins and their functions, as well as the organization of the cytoskeleton. The behaviour of the red cell is also striking in its development and maturation, undergoing vast changes in composition, appearance and variety of catalytic functions in its voyage f

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The Loss of Enzyme Activity from Erythroid Cells During Maturationell (1). The kinetics of this decay have usually been assumed to be a simple exponential function, that is, occurring continually throughout the life of the cell. In this view, erythrocyte death was often thought to be determined by one or more critical enzymes decaying to a threshold level that was

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Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Agingient biological mechanism that is not fully understood. It is commonly accepted that senescent erythrocytes are selectively recognized and removed from the circulation by spleen and liver macrophages (1), however, various mechanisms have been proposed to account for this selectivity (for a review se

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KCl Cotransport in HbAA and HbSS Red Cells: Activation by Intracellular Acidity and Disappearance Dud cells. Rheological experiments indicated that cell dehydration via the KCl cotransporter in response to low pH decreased the filterability of HbSS red cells. . maturation experiments showed that the KCl cotransport system was rendered cryptic rapidly, in contrast to choline transport, and serine t

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