Titlebook: Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology; Scientific and Clini M. R. Nowrousian Book 20021st edition Springer-Verlag/W

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Recombinant Human Erythropoietin (rhEPO) in Clinical OncologyScientific and Clini

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Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology978-3-7091-7658-0

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Use of recombinant human erythropoietin in the treatment of myelodysplastic syndromes,kemia. Although the clinical course of these disorders is highly variable from patient to patient, the International Prognostic Scoring System (Greenberg et al. 1997) provides an improved method for evaluating prognosis in individual MDS patients (Sanz et al. 1998).

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Pathophysiology of cancer-related anemia, 1983; Zucker 1985; Kreuzer et al. 1997; Tiziana and Caligaris-Cappio 1997; Voulgari et al. 1999). This type of anemia, referred to as the anemia of chronic disease (ACD), accounts for 52% of anemias in patients without blood loss, hemolysis or hematologic malignancies. In 19% of cases with ACD, cancer is the cause of anemia (Cash and Sears 1989).

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Incidence and impact of anemia in radiation oncology,ined and most radiotherapists did not focus on the prognostic impact of anemia in daily work. The main question over the recent years has concentrated on whether or not the well-known association between anemia and survival reflects a causal relationship or represents only an epiphenomemon (Fyles et al. 2000).

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Book 20021st editionously thought. Beyond clinical symptoms, anemia significantly impairs physical and metabolic functions as well as patients‘ activity, well-being and quality of life. Life expectancy is also affected. In this book, written by a group of outstanding international experts, the current knowledge on anem

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Biology of erythropoietin,(EpoR) and the Epo-induced intracellular signaling events. Finally, we will describe other compounds and mechanisms which mimic Epo action, thereby also leading to intracellular signalling albeit with a decreased efficiency when compared to Epo.

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Classification and characterization of anemia in cancer,y adults, hemoglobin levels range between 13.3–17.7 g/dl in men and 11.7–15.7 g/dl in women (Williams 1988; Fairbanks and Tefferi 2000). According to the World Health Organization, values below 13 g/dl in men and 12 g/dl in women are defined as anemia (World Health Organization 1968).

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