| 書目名稱 | Receptor-Mediated Endocytosis | | 編輯 | P. Cuatrecasas,T. Roth | | 視頻video | http://file.papertrans.cn/824/823556/823556.mp4 | | 叢書名稱 | Receptors and Recognition | | 圖書封面 |  | | 描述 | This volume focuses exclusively on those endocytic processes that sequester proteins by a selective, receptor-mediated mechanism. In such an endocytic process, cell surface receptors specifically bind protein ligands and localize them to specialized invaginations of the plasma membrane. These regions are coated pits, so named because they are lined on the cytoplasmic face with an ordered array of the protein, clathrin. It is this ‘coat‘ which provides their characteristic electron microscopic image. Subsequently, these regions pinch off to form coated vesicles which rapidly lose their ‘coat‘ and then fuse with other organelles or the plasma membrane. The hallmarks of ,this process are the specific receptors, coated pits, coated vesicles and an ordered sequence of transit events leading to delivery to selected locations. Receptor recognition, specific disposition of the endocytosed ligand and the existence of recep- tor-ligand complexes at highest density in coated pits define the process as selective and concentrative. This topic has received ever increasing attention during the past few years. The evolving mechanisms are especially exciting because they come at a time when the con | | 出版日期 | Book 1983 | | 關(guān)鍵詞 | Organelle; growth factor; lipoprotein; membrane; protein; research | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-009-5975-0 | | isbn_softcover | 978-94-009-5977-4 | | isbn_ebook | 978-94-009-5975-0 | | copyright | Springer Science+Business Media Dordrecht 1983 |
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