Titlebook: Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease; Deric L. Wheeler,Yosef Yarden Book 2015 Springer Science+Busine

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Judicious

Epithelium

fertilizer

Receptor Tyrosine Kinase Signal Transduction and the Molecular Basis of Signalling Specificity,rations in cancer and metabolic diseases. Since the cloning of the first RTK (the EGF receptor) 30 years ago, considerable progress has been made in the structural biology of both the extracellular domains and the tyrosine kinase domains of many members of the RTK superfamily. These studies have fir

背帶

觀點(diǎn)

Computational and Modeling Aspects of RTK Networks, to the cytoplasm and nucleus of target cells. Here we focus on one subgroup of receptor tyrosine kinases, whose prototype is the epidermal growth factor receptor (EGFR). Due to ligand-induced homo- and heterodimerization by EGFR (also called ERBB1) and other family members, extracellular signals ar

Console

Endocytosis and Endosomal Sorting of Receptor Tyrosine Kinases,g of internalized RTKs to lysosomes for degradation. Rapid internalization and efficient sorting of an activated RTK to lysosomes lead to a dramatic reduction in the cellular level of an RTK protein, a phenomenon called ligand-induced RTK downregulation. Endocytic trafficking is the major regulator

鋼筆尖

Dawdle

Retrieval