Titlebook: Receptor Tyrosine Kinases: Family and Subfamilies; Deric L. Wheeler,Yosef Yarden Book 2015 Springer International Publishing Switzerland 2

inferno

Coordinate

哄騙

The INSR/IGF1R Receptor Family,s splicing event leads to the generation of two isoforms, INSR-A and INSR-B, which lack or contain, respectively, exon 11. Overexpression of the IGF1R constitutes a typical hallmark of most types of cancer. The IGF1R exhibits a potent anti-apoptotic activity which confers upon IGF1R-expressing cells

BATE

bleach

The MuSK Receptor Family,fferentiation. MuSK is a type I transmembrane protein, related to ROR kinases, with an extracellular region that is composed of three Ig-like domains and a Frizzled-like domain. One face of the first Ig-like domain has a critical role in MuSK dimerization, whereas the opposing face of this Ig-like d

grenade

Fallibility

The ROR Receptor Family,that regulates diverse cellular functions and behaviors, including cellular polarity, migration, and invasion. In this chapter, we will provide a current overview of the Ror-family RTKs, with an emphasis on their expression patterns and roles during development, and their functional significance in

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Cpap155

The RYK Receptor Family, survival, proliferation, drug resistance, axon pathfinding and topographic mapping, migration, and the selection of appropriate target sites by cell processes. Sequential Notch-like proteolytic events that target distinct sites in RYK contribute in significant but mechanistically ill-defined ways t

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