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Titlebook: Recent Advances in Cell Biology of Acute Leukemia; Impact on Clinical D Wolf-Dieter Ludwig,Eckhard Thiel Conference proceedings 1993 Spring

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書目名稱Recent Advances in Cell Biology of Acute Leukemia
副標(biāo)題Impact on Clinical D
編輯Wolf-Dieter Ludwig,Eckhard Thiel
視頻videohttp://file.papertrans.cn/823/822636/822636.mp4
叢書名稱Recent Results in Cancer Research
圖書封面Titlebook: Recent Advances in Cell Biology of Acute Leukemia; Impact on Clinical D Wolf-Dieter Ludwig,Eckhard Thiel Conference proceedings 1993 Spring
描述The development of new techniques such as immuno- phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono- clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho- genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo- somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop- ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical
出版日期Conference proceedings 1993
關(guān)鍵詞Acute Leukemia; Akute Leuk?mien; Antigen; Cytogenetics; Immunophenotype; Immunph?notype; Molecular-cell bi
版次1
doihttps://doi.org/10.1007/978-3-642-84895-7
isbn_softcover978-3-642-84897-1
isbn_ebook978-3-642-84895-7Series ISSN 0080-0015 Series E-ISSN 2197-6767
issn_series 0080-0015
copyrightSpringer-Verlag Berlin Heidelberg 1993
The information of publication is updating

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Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia TCR chains, e.g. βδ, or surface expression of single chains apparently does not occur in normal T cells, although such phenomena have been described as rare events in leukemic cell lines (Hochstenbach and Brenner 1989).
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Molecular Genetic Techniques for Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemon, the development of methods to monitor individual responses of patients, to detect impending relapses prior to clinical manifestation, or to determine the quality of a bone marrow scheduled for autologous trans-plantation represents a major challenge of today’s oncology.
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Immunological, Ultrastructural and Molecular Features of Unclassifiable Acute Leukaemiaunophenotyping by analyzing the membrane expression of myeloid and B- and T-lymphoid antigens recognized by lineage-specific monoclonal antibodies (MoAbs) (Chan et al. 1985). Membrane marker analysis was first shown to be essential to characterize acute lymphoblastic leukemia (ALL) (Greaves et al. 1
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Myeloid-Associated Antigen Expression in Childhood Acute Lymphoblastic Leukemiath this aberrant antigen expression (myA. ALL) ranged from 5% to over 20% in pediatric series (Weiner et al. 1985; Ludwig et al. 1990; Pui et al. 1990; Wiersma et al. 1991) and was even higher in adult ALL (Sobol et al. 1987; Childs et al. 1989). The prognostic relevance of myeloid- associated antig
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