Titlebook: Recent Advances and Challenges in the Treatment of Major Depressive Disorder; Yong-Ku Kim Book 2024 The Editor(s) (if applicable) and The

antecedence

Endocrinological Treatment Targets for Depressive Disorderssion risk in susceptible subjects. Consequently, extensive research has explored treatment strategies involving the endocrine system. Treatment guidelines recommend tri-iodothyronine augmentation for resistant depression, while allopregnanolone analogs have gained approval for postpartum depression

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Efficacy, Safety, and Tolerability of Psychedelics in Treatment-Resistant Depression (TRD) long-lasting antidepressant effect far beyond the biological presence of the drug in the body, strongly indicating that downstream mechanisms activated by signaling cascades in the brain are involved. The present chapter describes the clinical development of psilocybin and esketamine for TRD and di

闡明

Probiotics and Fecal Microbiota Transplantation in Major Depression: Doxa or Episteme?l and clinical studies on the effectiveness and safety of these applications in depression. The information obtained from these studies may still be at a doxa level. However, the probability that this information will become episteme in the future seems to be increasing.

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Repetitive Transcranial Magnetic Stimulation (rTMS) in Major Depressionhough the exact rTMS mechanisms of action are not completely understood, rTMS seems to cause its beneficial effects through changes in neuroplasticity. Devices and protocols for rTMS are still evolving, becoming more efficient over time. There are still some challenges to be addressed, including fur

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Deep Brain Stimulation (DBS) in Treatment-Resistant Depression (TRD): Hope and Concernd outcomes and the challenges posed by placebo effects and trial design. Safety and ethical considerations are also discussed. Finally, we explore innovative directions for DBS research, including the potential of closed-loop systems, dual stimulation strategies, and noninvasive alternatives like ul

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Electroconvulsive Therapy (ECT) in Major Depression: Oldies but Goodiesoconvulsive therapy in depressed patients. By reviewing and integrating the results of the latest studies on the above matters, we aim to present the usefulness of electroconvulsive therapy for improving the personalized prognosis of patients with treatment-resistant depression.

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Cognitive Behavioral Therapy and Mindfulness-Based Cognitive Therapy for Depressive Disorders: Enhanan overview of the principles and evidence base for CBT and MBCT as well as different delivery modes for depressive disorders in adults. Finally, chances and challenges of integration are discussed as implications for practice, as well as recommendations and ideas for future research.

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The Potential and Challenges of Virtual Reality as an Adjunctive Treatment of Depression Patientstructuring. Various VR assessment techniques including biomarkers and machine learning have been discussed in this study. Although the field remains experimental, the immersive nature of VR holds the potential for more personalized and accurate therapeutic interventions and assessments. Further rese