Titlebook: Oxidants and Antioxidant Defense Systems; Tilman Grune Book 2005 Springer-Verlag Berlin Heidelberg 2005 Antioxidants.Biom.Biomarker.DNA re

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Chemical Modifications of Biomolecules by Oxidants,ress. Normally, the regulation of reduction/oxidation is vital for maintenance of cellular homeostasis. However, in conditions of excess free radicals, most intracellular substrates can be damaged, frequently leading to dysfunction and possibly disease. Whilst oxidants such as the hypohalous acids a

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The Broad Spectrum of Responses to Oxidative Stress in Proliferating Cells, hydrogen peroxide, for example 3–15 μM, or 0.1–0.5 mmol 10. cells, cause a significant mitogenic response with 25–45% growth stimulation. Higher H.O. concentrations of 120–150 μM, or 2–5 μmol 10. cells, cause a temporary growth-arrest that appears to protect cells from excess energy usage and DNA d

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Superoxide Dismutases and Catalase,ly all types of aerobic cells. Both are metalloproteins, employing efficient dismutation reactions to dispose of the two most common reactive oxygen species formed, the superoxide radical anion and hydrogen peroxide. These very fast reactions do not require reducing equivalents and thus energy input

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Modulation of Cellular Signaling Processes by Reactive Oxygen Species,ion of cellular stress signaling pathways. The modes of activation of these signaling cascades include the direct interaction of ROS with signaling proteins, i.e., their oxidation, or the indirect action of ROS via biomolecule oxidation products that, in turn, modulate the activities of signaling pr

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