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Titlebook: Razoxane and Dexrazoxane - Two Multifunctional Agents; Experimental and Cli Kurt Hellmann,Walter Rhomberg Book 2011 Springer Science+Busine

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發(fā)表于 2025-3-21 18:04:08 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Razoxane and Dexrazoxane - Two Multifunctional Agents
副標(biāo)題Experimental and Cli
編輯Kurt Hellmann,Walter Rhomberg
視頻videohttp://file.papertrans.cn/822/821689/821689.mp4
概述Selectively summarizes the >900 publications on these drugs comprehensive overview But cites most papers Shows where lacunae are
圖書封面Titlebook: Razoxane and Dexrazoxane - Two Multifunctional Agents; Experimental and Cli Kurt Hellmann,Walter Rhomberg Book 2011 Springer Science+Busine
描述Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms.They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc.The protection of normal tissues is nowhere
出版日期Book 2011
關(guān)鍵詞Radiaton Oncology
版次1
doihttps://doi.org/10.1007/978-90-481-9168-0
isbn_softcover978-94-017-8048-3
isbn_ebook978-90-481-9168-0
copyrightSpringer Science+Business Media B.V. 2011
The information of publication is updating

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發(fā)表于 2025-3-21 23:54:52 | 只看該作者
Kurt Hellmannines and modelling steps from the . methodology, which provides a bottom-up approach for engineering collaborative multi-agent societies with an emergent behaviour..The resulting MAS has self-adaptation properties, having agents that are able to change their behaviour according to changes in the env
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Kurt Hellmann,Walter RhombergSunday. Such data, he argued, would be a crucial weapon in the confessional conflict with the Protestants and also demonstrate the modern administrative standards of the church. Krose began publishing his own annual compilation of data in 1908 and set up a provisional office for church statistics in
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Kurt Hellmann,Walter Rhombergsed precisely this point. The political system had ‘to face the fact’, Schmidtchen argued, ‘that an archaic age would come to an end, during which people believed that social insights … would emerge automatically’. Polling, already ‘a(chǎn)n informal institution in the large democratic states’, would repl
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Dexrazoxane,ibit topoisomerase II..Chapter 3 is concerned essentially with dexrazoxane (ICRF-187) the dextro enantiomer of razoxane (ICRF-159). Although dexrazoxane was initially developed as an anticancer agent (like razoxane) it subsequently emerged as an interesting drug with unexpected properties. Introduct
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發(fā)表于 2025-3-23 06:40:15 | 只看該作者
Book 2011ll analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc.The protection of normal tissues is nowhere
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