Titlebook: Raynaud’s Phenomenon; From Pathogenesis to Fredrick M. Wigley,Ariane L. Herrick,Nicholas A. F Book 2024Latest edition The Editor(s) (if app

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Angiography,mia in between episodes of vasospasm should be further interrogated. Unilateral symptoms, atherosclerotic risk factors, associated connective tissue disorders, and tissue loss are among the clues that should heighten one’s suspicion that there is a fixed arterial obstruction. After the vascular labo

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,Statistical Design and Reporting of Randomised Controlled Trials for Raynaud’s Phenomenon,ded that they are designed and analysed in an appropriate fashion. We describe some important design and analysis considerations relating to RCTs for RP, including choice of outcome measure, seasonality, and heterogeneity of the conditions. We address some persistent misunderstandings around RCTs in

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,Non-drug Approaches to Treating Raynaud’s Phenomenon,d digital warmth; (2) avoiding medications that may trigger attacks; (3) smoking cessation; (4) behavioral interventions to manage emotional stress; and (5) other approaches, such as laser therapy or acupuncture. In this chapter, evidence related to non-drug approaches that have been suggested or tested for treating RP is discussed.

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,Statistical Design and Reporting of Randomised Controlled Trials for Raynaud’s Phenomenon,RP, including choice of outcome measure, seasonality, and heterogeneity of the conditions. We address some persistent misunderstandings around RCTs including concerns relating to imbalance in participant characteristics, the concept of placebo response, and our capacity to learn who will benefit from a particular treatment.

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,Raynaud’s Phenomenon in the Pediatric Age,reassurance to the child and family that this condition is relatively benign. Identification of a child with secondary RP or at high risk to progression to secondary RP based on history, examination, and investigations is important to allow more careful monitoring and follow-up, with the aim to detect evolving CTD early.