Titlebook: Rare Hereditary Cancers; Diagnosis and Manage Gabriella Pichert,Chris Jacobs Book 2016 Springer International Publishing Switzerland 2016 C

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Diagnosis and Management of Hereditary Renal Cell Cancer,al type and molecular pathogenesis. Insight into molecular pathogenesis has led to the development of targeted systemic therapies. Genetic susceptibility is the principal cause of RCC in about 2–4?% of cases. Hereditary RCC is the umbrella term for about a dozen different conditions, the most freque

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Diagnosis and Management of Hereditary Adrenal Cancer,cy with unfavourable prognosis. Recent advances in the molecular understanding of adrenal cancer offer promise for better therapies in the future. Many of these advances stem from the molecular elucidation of genetic conditions predisposing to the development of ACC. Six main clinical syndromes have

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Diagnosis and Management of Hereditary Carcinoids,rointestinal tract. There has been a move away from the use of the term carcinoid tumour to the more appropriate use of neuroendocrine tumour (NET) to highlight the potential for invasion and metastasis associated with some NETs. Although most cases are sporadic, 15–20?% of cases are related to a he

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Diagnosis and Management of Hereditary Sarcoma,etic component to sarcomas, and many familial cancer syndromes have been described, in which sarcomas are a feature. The best known of these are the Li–Fraumeni and retinoblastoma syndromes, study of which has been pivotal to elucidating the molecular basis for the cell response to DNA damage and th

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Diagnosis and Management of Hereditary Basal Cell Skin Cancer,, most likely to affect fair-skinned individuals exposed to ultraviolet (UV) radiation. This chapter focusses on the approach to recognising the relatively few individuals in whom a high-risk hereditary susceptibility may be present. Gorlin syndrome is the main consideration and the gene most common

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Genetic Testing for Rare Cancer: The Wider Issues,r the patient with cancer, their relatives and the health professionals caring for them. The specific risks and management issues associated with rare cancer types have been addressed in the earlier chapters. This chapter considers the wider issues involved in genetic counselling and genetic testing

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Diagnosis and Management of Hereditary Adrenal Cancer, been described to be associated with hereditary adrenal cancer. In these conditions, genetic counselling plays an important role for the early detection and follow-up of the patients and the affected family members.