Titlebook: Rare Disease Drug Development; Clinical, Scientific Raymond A. Huml Book 2021 The Editor(s) (if applicable) and The Author(s), under exclus

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Rare Diseases in the Pediatric Population,ses numerous challenges. In the past, there was a lack of commercial interest from drug manufacturers in developing new therapies due to high cost per patient and the likelihood of low profitability. The very small pools of patients, sometimes 200 or even fewer worldwide, makes clinical trials diffi

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The Feasibility Assessment,appropriate investigators and sites, attention must also be given to the patients required for clinical trial participation. Patients with rare and ultra-rare diseases often know and understand their disease better than their treating physicians. Working with patients early on in study planning to u

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d of molecular-clock dating and topics in the intersection of earth sciences with forensics. The content covers a broad range of techniques and applications.All major accepted dating techniques are included, as well as all major datable materials. .978-94-007-6304-3Series ISSN 1388-4360 Series E-ISSN 1871-756X

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Raymond A. Humld of molecular-clock dating and topics in the intersection of earth sciences with forensics. The content covers a broad range of techniques and applications.All major accepted dating techniques are included, as well as all major datable materials. .978-94-007-6304-3Series ISSN 1388-4360 Series E-ISSN 1871-756X

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