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Titlebook: Randomised Controlled Clinical Trials; Christopher J. Bulpitt Book 1996Latest edition Springer Science+Business Media New York 1996 drugs.

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Writing The Protocol, and lastly supplying a permanent record of what was intended in the trial. The same document may serve all these functions, and in addition a section on finances may be included when the document is used as a grant application.
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Analysis of the Results, Subgroup and Meta-Analysis,nd scope of this book to describe in detail the statistical methods required to analyse the results of randomised controlled trials. The reader is referred to standard texts such as the books by Armitage and Berry [290], Everitt [291] and Bailar and Mosteller [292].
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nalysis are all new sections. Thereferences are expanded from 305 to 512 and include the recentadvances in trial design, such as the .n.-of-1 trials andmegatrials, and up-to-date examples to illustrate the points made inthe 20 chapters.978-1-4613-7915-7978-1-4615-6347-1
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The Objectives of a Randomised Controlled Trial,an investigator may be interested in a trial of a new antihypertensive drug in elderly patients. The major objective could be either to demonstrate the efficacy of the drug in lowering blood pressure or in preventing cardiovascular deaths. The first objective could be answered in a few patients stud
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