Titlebook: Radiobiology of Glioblastoma; Recent Advances and Luigi Pirtoli,Giovanni Luca Gravina,Antonio Giorda Book 2016 Springer International Publ

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Genetic and Epigenetic Determinants in Tumor Initiation and Progression of Glioblastomagenesis. The recent genome-wide sequencing and large-scale epigenetic profiling studies have generated crucial new data into the interplay between genetic and epigenetic alterations in glioblastoma, leading to a better understanding of the genetics and epigenetics determinants in the different gliom

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Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomidemmed cell death (PCD) in mammalian tissues. Resistance to apoptosis was closely linked to tumorigenesis, and has taken a central position in cell death research. However, in the last years it has become evident that radiotherapy as well as other therapeutic agents, including temozolomide (TMZ) are a

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miRNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models are also endogenous molecular weapons of the tumor cells to respond to therapy: in human glioblastoma multiforme (GBM) cells miRNA can counteract the radiation effects interfering with signal transduction cascaded or controlling the fate of the cell by the regulation of programmed cell death proces

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2197-781X etting.Written by experts in the field.Bridges the gap of kn.This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the cli

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miRNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Modelsproach to favorably interfere within the altered gene network of human brain tumors..In this review, we highlight the state of the art of the capacity of miRNA to modulate the behavior of glioblastoma cells to ionizing radiation preclinical schemes.