| 書目名稱 | RUNX Proteins in Development and Cancer |
| 編輯 | Yoram Groner,Yoshiaki Ito,Andre van Wijnen |
| 視頻video | http://file.papertrans.cn/821/820246/820246.mp4 |
| 概述 | Provides readers with an overview of the diverse functions of the RUNX family genes.Is a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists |
| 叢書名稱 | Advances in Experimental Medicine and Biology |
| 圖書封面 |  |
| 描述 | .This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three .RUNX. genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy...The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where .RUNX1. and .CBFB. are frequently affected by chromosomal translocations that generate fusion oncopr |
| 出版日期 | Book 2017 |
| 關(guān)鍵詞 | CBFb; DNA damage response; RUNX; epigenetic memory; lineage-specific developmental regulators |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-10-3233-2 |
| isbn_softcover | 978-981-10-9822-2 |
| isbn_ebook | 978-981-10-3233-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | This is a U.S. Government work and not under copyright protection in the U.S.; foreign copyright pro |
|Archiver|手機版|小黑屋|
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